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Mission
To drive precision cancer medicine through clinical computational oncology:
We are always looking for motivated scientists (computational biologists, post-doctoral fellows, etc) - if you're interested please reach out! |
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News 3.1.25 - A new method to think about analyzing clinical cancer single cell cohorts for hypothesis generation 2.10.25 - Genomic mediators of acquired resistance to immunotherapy in melanoma 1.2.25 - Germline structural variants that contribute to risk for pediatric cancers 12.4.24 - Evolution of myeloid-mediated immunotherapy resistance in prostate cancer 7.1.24 - Welcome Sherin, David, and Tess! 6.5.24 - Congrats Kevin on your successful PhD defense! 5.14.24 - Examining clinically actionable structural variants in melanoma genomes 5.1.24 - Welcome Parker! 3.21.24 - Opportunities in AI and oncology across research and clinical domains 3.18.24 - Congrats to Nicita Mehta on your successful PhD defense! 3.8.24 - Identifying inherited rare variants and their relationship to renal cell carcinoma development 2.26.24 - Congrats to Samantha Hoffman on your successful PhD defense! 1.8.24 - Historical perspective and future directions: computational science in immuno-oncology 10.26.23 - Artificial Intelligence is Here: What Does it Mean for Patients? (video) 10.15.23 - Welcome Noah and Marc! 9.27.23 - Dissecting the tumor and immune cellular states in GI neuroendocrine tumors 9.19.23 - Biologically interpretable computer vision deep learning to learn tumor and immune states in kidney cancer 7.1.23 - Welcome Julie and Andreanne! 5.2.23 - Congrats to Seunghun Han on your successful PhD defense! 4.3.23 - Welcome Claire and welcome back Shreya! 3.3.23 - Congrats to Jackson Nyman on your successful PhD defense! 1.5.23 - Welcome Gwen! 10.1.22 - Welcome Ahmed and Ryan! 9.8.22 - The mutational footprint of platinum chemotherapy exposure in a secondary thyroid cancer 8.19.22 - Creating patient-partnered cancer research for prostate cancer through mpcproject.org 8.1.22 - Welcome Laura, Yun Jee, Yuxi, and Alex! 7.18.22 - Cancer ethics and artificial intelligence research 5.2.22 - Welcome Marc! 4.29.22 - Inherited mutations in DNA repair genes and pediatric sarcomas 4.8.22 - Genome-wide patterns of somatic mutations in cancer genomes 2.2.22 - Welcome Alina and Matías! 12.1.21 - Welcome Samantha, Caroline, and Karthik! 11.15.21 - Congrats to Jake Conway on your successful PhD defense! 9.30.21 - The Molecular Oncology Almanac for clinical implementation of precision cancer medicine 9.22.21 - Biologically informed deep neural network for prostate cancer discovery and translation 9.21.21 - Molecular analysis of combination immunotherapy + chemotherapy in triple negative breast cancer 9.7.21 - Investigating exceptional responders to anti-androgen therapy in localized prostate cancer 6.28.21 - Welcome Erin! 6.7.21 - Partner and collateral dependencies from fusions in cancer cells 5.3.21 - Congrats to Dr. Meng Xiao He on your successful PhD thesis defense! 3.11.21 - Tumor and immune transcriptional reprogramming in metastatic kidney cancer treated with immune checkpoint blockade 3.4.21 - Transcriptional mediators of treatment resistance in metastatic prostate cancer using single cell analysis 2.5.21 - Integrated molecular analysis of sarcomatoid/rhabdoid renal cell carcinoma histologic variant 2.1.21 - Welcome Maha and Erica! 2.7.21 - Welcome Gha Young and Kathryn! 2.5.21 - Molecular analysis of sarcomatoid/rhabdoid renal cell carcinoma 2.1.21 - Welcome Jingxin! 12.16.20 - Welcome to Nicita, Surya, and Pauline! 12.15.20 - Congrats to Alice and Iris completing their Masters Capstone projects and next steps! 11.30.20 - Tumor, immune, and spatial correlates of WEE1/cisplatin in breast cancer 11.23.20 - Integrating > 1000 melanoma exomes to find coordinated biological and clinical states 11.17.20 - Detecting germline pathogenic mutations using deep learning methods 11.4.20 - Evaluating PBRM1 mutations in a retrospective clinical cohort 10.16.20 - Fall book club on genetics and eugenics 8.10.20 - Weclome Shreya and Filipe! 7.17.20 - Summer book club discussion on Notes of a Native Son (Baldwin) 6.29.20 - Welcome Breanna, Kevin, and Aditi! 6.25.20 - Understanding genomic testing in cancer immunotherapy 6.5.20 - Visualizing genomics + clinical data with comutation plots 4.1.20 - Welcome Alexis! 3.3.20 - Connecting germline features and immune infiltration in solid tumors 2.4.20 - Selective immunotherapy response and genomics in breast cancer 2.2.20 - Using expanded nucleotide context to identify cancer genes 12.2.19 - Integrative predictive modeling of cancer immunotherapy response 11.12.19 - Harmonizing tumor mutational burden across assays in lung cancer 9.9.19 - Discussing a key professional moment of inspiration 9.4.19 - Validation of PBRM1 mutations in a phase 3 clinical trial 7.1.19 - Welcome Cora, Sabrina, Jett, Vidal, and Keyan! 6.21.19 - Tumor genomics and chemoradiation resistance in rectal cancer 6.4.19 - Genomic evolutionary patterns in leiomyosarcoma and liposarcoma 6.1.19 - Bittersweet goodbyes to Claire (Verana Health), Scanner (NYU MD program), and Eric (UCSD PhD program) - good luck on your next adventures! 3.25.19 - Reviewing the current state of clinical genomics and cancer immunotherapy 2.1.19 - Welcome Julia, Alice, Alok and Angel! 1.24.19 - Germline CHEK2 mutations and risk for germ cell tumors 1.2.19 - Welcome Kevin! 11.18.18 - Patient-driven cancer genomic data liberation 9.4.18 - Prostate cancer immunogenomics and clinical outcomes 8.27.18 - Cancer genomics and immunotherapy in microsatellite stable tumors 8.20.18 - Welcome [clears throat] Allison, Jackson, Seunghun, Nick, David! 8.16.18 - Finding new cancer neoepitopes in RNA 6.1.18 - Welcome Tanya, Scanner, and Derek! 5.30.18 - Bittersweet goodbyes to Stephanie (off to UCSF PhD program) and Noora (MS complete!) - good luck on your next adventures! 5.10.18 - Congrats Noora on your M.S. thesis defense in Computational Biology & Quantitative Genetics! 4.5.18 - PanCanAtlas TCGA oncogenic signaling pathways marker paper 4.2.18 - The long tail of oncogenic drivers in prostate cancer 3.1.18 - Inherited DNA repair defects in colorectal cancer 2.25.18 - Wall St Journal feature on the Metastatic Prostate Cancer Project and patient-partnered research! 2.19.18 - NY Times feature that includes our work on cancer immunotherapy and genomics 1.5.18 - Interactive or static genomics reports for precision cancer medicine 1.4.18 - Genomics, chromatin dysregulation, and immunotherapy response in kidney cancer! 12.19.17 - Mutational patterns in chemoresistant bladder cancer - congrats Dave! 12.11.17 - Genomic resistance to second-generation androgen blockade in paired tumor biopsies of metastatic castration-resistant prostate cancer (and best of luck to Celine on next adventure!) 11.30.17 - Tumor histocompatibility in cancer 9.13.17 - Welcome Eric and Noora! 9.5.17 - Pros and perils of expanded germline testing in cancer 7.1.17 - Welcome Shuming and Jake! 6.30.17 - Bittersweet goodbyes to Diana and Nate as they return to medschool - good luck, and don't forget to get coffee for the interns 6.15.17 - Got a preclinical finding you think might be clinically relevant? Pitch it here: salsa.broadinstitute.org 6.1.17 - Welcome Haitham! 4.6.17 - Welcome Natalie! 2.21.17 - Response and genomic resistance to PD-1 blockade in sarcoma 1.4.17 - Welcome Shirley! 12.15.16 - Welcome Felix! 12.1.16 - Genomic origin and evolution of chemoresistance in germ cell tumors 11.2.16 - Guest editing a special edition of Genome Medicine focused on precision oncology 10.19.16 - Genomic heterogeneity and exceptional response to combination targeted therapies 8.31.16 - Welcome Claire and Amaro! 7.26.16 - Optimizing tumor only genomic analysis for cancer precision medicine 7.6.2016 - Practice changing finding: Inherited DNA-repair mutations in advanced prostate cancer - 6.15.2016 - Clinical validation of (the first) genomic biomarker of platinum chemotherapy response in bladder cancer 6.1.2016 - Welcome Meng Xiao and Saud! And congrats to Andrea, off to Stanford Med! 5.26.2016 - Exciting clinical computational oncology work @ASCO from the lab re: immunotherapy and chemotherapy resistance, clinical genomic panel testing, and more! 4.25.2016 - Unique mutational signature in ERCC2 mutant bladder tumors 3.25.2016 - Clonal neoantigens and immunotherapy response 12.10.2015 - Inherited genomes after severe environmental exposure (chemotherapy) are unaffected! 12.1.2015 - Welcome Jihye and Alicia! 10.22.2015 - Talking clinical computational oncology at Science for All Seasons 9.10.2015 - Genomics and immunotherapy in melanoma 8.5.2015 - Welcome Celine! 7.15.2015 - Welcome Dave and Stephanie! 7.14.2015 - Genomics and exceptional responder for cancer immunotherapy 6.19.2015 - Expansive genomic classification of melanoma 6.8.2015 - Welcome Brendan! 5.21.2015 - The clinically actionable genome of metastatic prostate cancer. 5.15.2015 - New ASCO course on clinical tumor genomics 5.11.2015 - Welcome Alma! 4.1.2015 - New resistance mediator to androgen deprivation therapy for advanced prostate cancer 3.5.2015 - Exceptional response to 14 days of erlotinib 2.14.2015 - Discovering mechanisms of clinical resistance to combination targeted therapies in colorectal cancer 1.30.2015 - President Obama's Precision Medicine Initiative 1.9.2015 - Welcome Diana and Travis! 1.7.2015 - Community annotations for TumorPortal.org now live. 1.1.2015 - Hello world. |
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