To drive precision cancer medicine through clinical computational oncology:
We are always looking for motivated scientists (computational biologists, post-doctoral fellows, etc) - if you're interested please reach out!
9.8.22 - The mutational footprint of platinum chemotherapy exposure in a secondary thyroid cancer
8.19.22 - Creating patient-partnered cancer research for prostate cancer through mpcproject.org
8.1.22 - Welcome Laura, Yun Jee, Yuxi, and Alex!
7.18.22 - Cancer ethics and artificial intelligence research
5.2.22 - Welcome Marc!
4.29.22 - Inherited mutations in DNA repair genes and pediatric sarcomas
4.8.22 - Genome-wide patterns of somatic mutations in cancer genomes
2.2.22 - Welcome Alina and Matías!
12.1.21 - Welcome Samantha, Caroline, and Karthik!
11.15.21 - Congrats to Jake Conway on your successful PhD defense!
9.30.21 - The Molecular Oncology Almanac for clinical implementation of precision cancer medicine
9.22.21 - Biologically informed deep neural network for prostate cancer discovery and translation
9.21.21 - Molecular analysis of combination immunotherapy + chemotherapy in triple negative breast cancer
9.7.21 - Investigating exceptional responders to anti-androgen therapy in localized prostate cancer
6.28.21 - Welcome Erin!
6.7.21 - Partner and collateral dependencies from fusions in cancer cells
5.3.21 - Congrats to Dr. Meng Xiao He on your successful PhD thesis defense!
3.11.21 - Tumor and immune transcriptional reprogramming in metastatic kidney cancer treated with immune checkpoint blockade
3.4.21 - Transcriptional mediators of treatment resistance in metastatic prostate cancer using single cell analysis
2.5.21 - Integrated molecular analysis of sarcomatoid/rhabdoid renal cell carcinoma histologic variant
2.1.21 - Welcome Maha and Erica!
2.7.21 - Welcome Gha Young and Kathryn!
2.5.21 - Molecular analysis of sarcomatoid/rhabdoid renal cell carcinoma
2.1.21 - Welcome Jingxin!
12.16.20 - Welcome to Nicita, Surya, and Pauline!
12.15.20 - Congrats to Alice and Iris completing their Masters Capstone projects and next steps!
11.30.20 - Tumor, immune, and spatial correlates of WEE1/cisplatin in breast cancer
11.23.20 - Integrating > 1000 melanoma exomes to find coordinated biological and clinical states
11.17.20 - Detecting germline pathogenic mutations using deep learning methods
11.4.20 - Evaluating PBRM1 mutations in a retrospective clinical cohort
10.16.20 - Fall book club on genetics and eugenics
8.10.20 - Weclome Shreya and Filipe!
7.17.20 - Summer book club discussion on Notes of a Native Son (Baldwin)
6.29.20 - Welcome Breanna, Kevin, and Aditi!
6.25.20 - Understanding genomic testing in cancer immunotherapy
6.5.20 - Visualizing genomics + clinical data with comutation plots
4.1.20 - Welcome Alexis!
3.3.20 - Connecting germline features and immune infiltration in solid tumors
2.4.20 - Selective immunotherapy response and genomics in breast cancer
2.2.20 - Using expanded nucleotide context to identify cancer genes
12.2.19 - Integrative predictive modeling of cancer immunotherapy response
11.12.19 - Harmonizing tumor mutational burden across assays in lung cancer
9.9.19 - Discussing a key professional moment of inspiration
9.4.19 - Validation of PBRM1 mutations in a phase 3 clinical trial
7.1.19 - Welcome Cora, Sabrina, Jett, Vidal, and Keyan!
6.21.19 - Tumor genomics and chemoradiation resistance in rectal cancer
6.4.19 - Genomic evolutionary patterns in leiomyosarcoma and liposarcoma
6.1.19 - Bittersweet goodbyes to Claire (Verana Health), Scanner (NYU MD program), and Eric (UCSD PhD program) - good luck on your next adventures!
3.25.19 - Reviewing the current state of clinical genomics and cancer immunotherapy
2.1.19 - Welcome Julia, Alice, Alok and Angel!
1.24.19 - Germline CHEK2 mutations and risk for germ cell tumors
1.2.19 - Welcome Kevin!
11.18.18 - Patient-driven cancer genomic data liberation
9.4.18 - Prostate cancer immunogenomics and clinical outcomes
8.27.18 - Cancer genomics and immunotherapy in microsatellite stable tumors
8.20.18 - Welcome [clears throat] Allison, Jackson, Seunghun, Nick, David!
8.16.18 - Finding new cancer neoepitopes in RNA
6.1.18 - Welcome Tanya, Scanner, and Derek!
5.30.18 - Bittersweet goodbyes to Stephanie (off to UCSF PhD program) and Noora (MS complete!) - good luck on your next adventures!
5.10.18 - Congrats Noora on your M.S. thesis defense in Computational Biology & Quantitative Genetics!
4.5.18 - PanCanAtlas TCGA oncogenic signaling pathways marker paper
4.2.18 - The long tail of oncogenic drivers in prostate cancer
3.1.18 - Inherited DNA repair defects in colorectal cancer
2.25.18 - Wall St Journal feature on the Metastatic Prostate Cancer Project and patient-partnered research!
2.19.18 - NY Times feature that includes our work on cancer immunotherapy and genomics
1.5.18 - Interactive or static genomics reports for precision cancer medicine
1.4.18 - Genomics, chromatin dysregulation, and immunotherapy response in kidney cancer!
12.19.17 - Mutational patterns in chemoresistant bladder cancer - congrats Dave!
12.11.17 - Genomic resistance to second-generation androgen blockade in paired tumor biopsies of metastatic castration-resistant prostate cancer (and best of luck to Celine on next adventure!)
11.30.17 - Tumor histocompatibility in cancer
9.13.17 - Welcome Eric and Noora!
9.5.17 - Pros and perils of expanded germline testing in cancer
7.1.17 - Welcome Shuming and Jake!
6.30.17 - Bittersweet goodbyes to Diana and Nate as they return to medschool - good luck, and don't forget to get coffee for the interns
6.15.17 - Got a preclinical finding you think might be clinically relevant? Pitch it here: salsa.broadinstitute.org
6.1.17 - Welcome Haitham!
4.6.17 - Welcome Natalie!
2.21.17 - Response and genomic resistance to PD-1 blockade in sarcoma
1.4.17 - Welcome Shirley!
12.15.16 - Welcome Felix!
12.1.16 - Genomic origin and evolution of chemoresistance in germ cell tumors
11.2.16 - Guest editing a special edition of Genome Medicine focused on precision oncology
10.19.16 - Genomic heterogeneity and exceptional response to combination targeted therapies
8.31.16 - Welcome Claire and Amaro!
7.26.16 - Optimizing tumor only genomic analysis for cancer precision medicine
7.6.2016 - Practice changing finding: Inherited DNA-repair mutations in advanced prostate cancer -
6.15.2016 - Clinical validation of (the first) genomic biomarker of platinum chemotherapy response in bladder cancer
6.1.2016 - Welcome Meng Xiao and Saud! And congrats to Andrea, off to Stanford Med!
5.26.2016 - Exciting clinical computational oncology work @ASCO from the lab re: immunotherapy and chemotherapy resistance, clinical genomic panel testing, and more!
4.25.2016 - Unique mutational signature in ERCC2 mutant bladder tumors
3.25.2016 - Clonal neoantigens and immunotherapy response
12.10.2015 - Inherited genomes after severe environmental exposure (chemotherapy) are unaffected!
12.1.2015 - Welcome Jihye and Alicia!
10.22.2015 - Talking clinical computational oncology at Science for All Seasons
9.10.2015 - Genomics and immunotherapy in melanoma
8.5.2015 - Welcome Celine!
7.15.2015 - Welcome Dave and Stephanie!
7.14.2015 - Genomics and exceptional responder for cancer immunotherapy
6.19.2015 - Expansive genomic classification of melanoma
6.8.2015 - Welcome Brendan!
5.21.2015 - The clinically actionable genome of metastatic prostate cancer.
5.15.2015 - New ASCO course on clinical tumor genomics
5.11.2015 - Welcome Alma!
4.1.2015 - New resistance mediator to androgen deprivation therapy for advanced prostate cancer
3.5.2015 - Exceptional response to 14 days of erlotinib
2.14.2015 - Discovering mechanisms of clinical resistance to combination targeted therapies in colorectal cancer
1.30.2015 - President Obama's Precision Medicine Initiative
1.9.2015 - Welcome Diana and Travis!
1.7.2015 - Community annotations for TumorPortal.org now live.
1.1.2015 - Hello world.